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Jessica Kramer

Assistant Professor of Biomedical Engineering and
Adjunct Assistant Professor of Pharmaceutics and Pharmaceutical Chemistry

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B.S. University of Utah

Ph.D. University of California, Los Angeles



Jessica Kramer's Lab Page

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Biological Chemistry Program

Polymer chemistry, protein engineering, bioconjugation techniques


My lab utilizes a combination of polymer chemistry, protein engineering, and bioconjugation techniques to address human health needs. We study fundamental glycobiology with the ultimate goal of developing glycoform targeted therapeutics. Current projects include 1) glycocalyx engineering to study the role of mucin glycoproteins in cancer; 2) synthetic epithelial mucus to model infection and absorption processes; 3) synthetic antifreeze proteins for cryopreservation of medical tissues and ultimately whole organs.


  1. Stacy A. Malaker, Kayvon Pedram, Michael J. Ferracane, Barbara A. Bensing, Venkatesh Krishnan, Christian Pett, Jin Yu, Elliot C. Woods, Jessica R. Kramer, Ulrika Westerlind, Oliver Dorigo, and Carolyn R. Bertozzi. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. 
  2. MN Zhou, CS Delaveris, Jessica R Kramer, JA Kenkel, EG Engleman, CR Bertozzi. N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2. Angew Chem Int Ed Engl. Doi: 10.1002/anie.201713075 (2018)
  3. Jessica R. Kramer, Bibiana Onoa, Carlos Bustamante, Carolyn R. Bertozzi. Chemically tunable mucin chimeras assembled on living cells. PNAS.
    doi: 10.1073/pnas.1516127112 (2015).
  4. Jessica R. Kramer,* Rosine Petitdemange,* Laure Bataille, Katell Bathany, Anne-Laure Wirotius, Bertrand Garbay, Timothy J. Deming, Elisabeth Garanger, and Sébastien Lecommandoux. Quantitative side-chain modifications of methionine-containing elastin-like polypeptides. ACS Macro Lett., 4, 1283–1286 (2015).
  5. Jessica R. Kramer,* Nathan W. Schmidt,* Kristine M. Mayle, Daniel T. Kamei, Gerard C. L. Wong, and Timothy J. Deming, Reinventing cell penetrating peptides using glycosylated methionine sulfonium ion sequences. ACS Cent. Sci., 2, 83–88 (2015).
  6. Jessica R. Kramer, and Timothy J. Deming. Deming. Recent advances in glycopolypeptide synthesis. Polym. Chem. 5, 671-682 (2014).
  7. Jessica R. Kramer, and Timothy J. Deming. Multimodal switching of conformation and solubility in homocysteine derived polypeptides. J. Am. Chem. Soc. 136, 5547–5550 (2014).
  8. April R. Rodriguez, Jessica R. Kramer, and Timothy J. Deming. Enzyme-triggered cargo release from methionine sulfoxide containing copolypeptide vesicles. Biomacromolecules 14, 3610–3614 (2013).
  9. Jessica R. Kramer, and Timothy J. Deming. Reversible Chemoselective tagging and functionalization of methionine containing peptides. Chem. Comm. 49, 5144–5146 (2013).
  10. Jessica R. Kramer,* April R. Rodriguez,* Uh-Joe Choe, Daniel T. Kamei, and Timothy J. Deming. Glycopolypeptide conformations in block copolymer assemblies influence both nanoscale morphology and ligand binding properties. Soft Matter 9, 3389–3395 (2013).
  11. Jessica R. Kramer, and Timothy J. Deming. Preparation of multifunctional and multireactive polypeptides via methionine alkylation. Biomacromolecules 13, 1719–1723 (2012).
  12. Jessica Kramer, Souren Soukiazian, Sky Mahoney, and Jocelyn Hicks-Garner. Microbial fuel cell biofilm characterization with thermogravimetric analysis on bare and polyethyleneimine surface modified carbon foam anodes. J. Power Sources 210, 122–128 (2012).
  13. Jessica R. Kramer and Timothy J. Deming. Glycopolypeptides with a redox-triggered helix-to-Coil Transition. J. Am. Chem. Soc. 134, 4112–4115 (2012).
  14. Jessica R. Kramer and Timothy J. Deming. General method for purification of α-amino acid-N-carboxyanhydrides using flash chromatography. Biomacromolecules 11, 3668–3672 (2010).
  15. Jessica R. Kramer and Timothy J. Deming. Glycopolypeptides via living polymerization of glycosylated-L-lysine N-carboxyanhydrides. J. Am. Chem. Soc. 132, 15068–15071 (2010).

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Last Updated: 5/5/21