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Andrew S. Weyrich

Professor of Internal Medicine and Adjunct Professor of Microbiology and Immunology

Vice President for Research at the University of Utah

Novel Functions of Platelets in Health and Disease

Andy Weyrich

 

Molecular Biology Program

Education

B.S. Baldwin-Wallace College

M.S. Wake Forest University

Ph.D. Bowman Gray School of Medicine

 

 

 

Research

Dr. Andrew S. Weyrich’s research examines how blood clots in health and disease. His group made the seminal discovery in 2005 that anucleate human platelets splice precursor messenger RNA into products that regulate inflammation. This paradigm shifting observation revolutionized the field of hematology, and has led to thousands of studies that use mRNA profiling to understand how platelets regulate thrombosis and inflammation - which is now referred to as "thromboinflammation".  Dr. Weyrich has delivered more than 100 national and international talks and keynote addresses, and he has received numerous investigator research awards from the Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), the International Society of Thrombosis and Haemostasis (ISTH), and the prestigious William Dameshek prize from the American Society of Hematology (ASH). The University of Utah has also recognized him with an H.A. and Edna Benning Presidential Endowed Chair and he recently received the John R. Hoidal Senior Investigator Award. Dr. Weyrich has published more than 150 peer-reviewed articles and has been funded by the National Institute of Health (NIH) for over 25 years, including during his tenure as the Vice President for Research (VPR). Dr. Weyrich is also a member of the esteemed NIH National Heart, Lung, and Blood (NHLBI) advisory council. 

 

U Research Leadership

In addition to Dr. Weyrich’s prolific research work, he also serves as the University of Utah’s Vice President for Research and President of the University’s Research Foundation and Innovation District since July 2016. Previous to these appointments, he was the Associate Dean of Research at the Health Sciences. As a leader of the U’s research community, Dr. Weyrich has implemented strategic initiatives and programs that continues to drive diverse and inclusive research excellence at the U and also contributes more than $500 million annually to the Utah economy. During his service, the U’s research portfolio has been on an upward trajectory with an average annual increase of 27% in extramural awards that totaled over $3.5 billion dollars. The U received national research recognitions including membership in the Association of American Universities and the Association of Public and Land-grant Universities (APLU) Innovation and Economic Prosperity designation. He has also launched numerous research programs, including critical topics in: Women in Violence; COVID-19; Opioid Crisis; and Equity, Diversity, and Inclusion in Research. Since assuming responsibility in 2019, Dr. Weyrich spearheaded important safety initiatives in research laboratories and work spaces to strengthen campus-wide safety that included restructuring of Environmental Health and Safety (EHS) and the development of stronger working relationships between EHS and research-intensive units. He also worked with UU Health Operations and the Research Cores to stand-up surveillance testing for the entire UU community. Dr. Weyrich’s support for future generations in research is built upon his passion for mentorship and student engagement. Dr. Weyrich has taught and mentored undergraduate, graduate, and medical students since his career began, and he currently directs training grant programs that support research for medical students and postdoctoral fellows. He also works closely with Undergraduate Research Programs at the U to help provide impactful resources to enhance the U student research experience and career mobility.

References

  1. Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-a secretion: signal integration and NF-kB translocation. J Clin Invest 95:2297-2303, 1995. PMCID: PMC295843.
  2. Weyrich AS, Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrissey JH, Prescott SM, Zimmerman GA. Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 97:1525-1534, 1996. PMCID: PMC507213.
  3. Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. PNAS 95:5556-5561, 1998. PMCID: PMC20416.
  4. Lindemann S, Tolley ND, Dixon DA, McIntyre TM, Prescott SM, Zimmerman GA, Weyrich AS. Activated Platelets Mediate Inflammatory Signaling by Regulated Interleukin-1b Synthesis. J Cell Biol 154: 485-490, 2001. PMCID: PMC2196422.
  5. Galt SW, Lindemann S, Allen L, Medd DJ, Falk JM, McIntyre TM, Prescott SM, Kraiss LW, Zimmerman GA, Weyrich AS. Outside-in signals delivered by MMP-1 regulate platelet function. Circ Res 90:1093-99, 2002.
  6. Weyrich AS, Denis MM, Kuhlmann-Eyre JR, Spencer ED, Dixon DA, Marathe GK, McIntyre TM, Zimmerman GA, Prescott SM. Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation 111:633-42, 2005.
  7. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122:379-391, 2005.
  8. Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, Kraiss LW, Albertine KH, McIntyre TM, Zimmerman GA. mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 109:1975-1983, 2007. PMCID: PMC1801071.
  9. Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich AS. PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood 113:6699-706, 2009. PMCID: PMC2710923.
  10. Schwertz H, Köster S, Kahr WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, and Weyrich AS. Anucleate platelets generate progeny. Blood 115:3801-9, 2010. PMCID: PMC2865870.
  11. Rowley JW, Oler A, Tolley ND, Hunter B, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS. Genome wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14):e101-11, 2011. PMCID: PMC3193274.
  12. Kahr WHA, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu G-Y, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nature Genetics, 43(8):738-40, 2011. NIHMSID: 595414.
  13. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WHA, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS. Novel anti-bacterial activities of β-defensin 1 in human platelets: Suppression of pathogen growth and signaling of neutrophil extracellular traps. PLoS Pathogens, 7(11):e1002355, 2011. PMCID: PMC3213094.
  14. Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich AS. In Vivo Platelet Activation in Critically-Ill Patients with Primary H1N1 Influenza. Chest, 141(6):1490-95, 2012. PMCID: PMC3367488.
  15. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS. Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood 120(25):5014-20, 2012.  PMCID: PMC3525025.
  16. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL. Abnormal megakaryocyte development and platelet function in Nbeal2-/- mice. Blood 122(19): 3349-58, 2013. PMCID: PMC3953091.
  17. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest 124(9):3757-66, 2014. PMCID: PMC4151230.
  18. Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet 47(5):535-538, 2015. PMCID: PMC4631613.
  19. Rowley JW, Chappaz S, Corduan A, Chong MMW, Campbell RA, Khoury A, Manne BK, Wurtzel JGT, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS.  Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets.  Blood, 127(14):1743-51, 2016. PMCID: PMC4825412.
  20. Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich AS. Clots are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis. Arterioscler Thromb Vasc Biol. 37(10):1819-1827, 2017. PMID: 28775073.
  21. Fidler TP, Campbell RA, Funari T, Denne N, Balderas AE, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED. Deletion of GLUT1 and GLUT3 Reveals Multiple roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep. 20(4):881-894, 2017. PMID: 28746873.
  22. Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT.  Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3.  Blood 133(19):2013-2026, 2019.  PMID:30723081.
  23. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT. Sepsis alters the transcriptional and translational landscape of human and murine platelets.  Blood 134(12):911-923, 2019.  PMID:31366617.
  24. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA. Platelet gene expression and function in patients with COVID-19. Blood 2020 Sep 10; 136(11): 1317–1329. PMCID: PMC7483430.
  25. Rondina MT, Voora D, Simon LM, Schwertz H, Harper JF, Lee O, Bhatlekar SC, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley ND, Kosaka Y, Weyrich AS, Bray PF, Rowley JW. Longitudinal RNA-Seq analysis of the repeatability of gene expression and splicing in human platelets identifies a platelet SELP splice QTL. Circ Res 126(4):501-516, 2020. PMID: 31852401.
  26. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood 136(10):1169-1179, 2020. PMID: 32597954.
Last Updated: 7/28/21