Luis Batista
Professor of Medicine and Oncological Sciences
Cancer Biology, Cell Biology, Developmental Biology, Biochemistry, Stem Cells, Development and Regenerative Medicine
Molecular Biology Program
Education
B.S. University of Sao Paulo
Ph.D. University of Sao Paulo and University of Mainz
Postdoctoral Scholar Stanford University
Research
Our research seeks to understand how mutations that affect genetic stability lead to cancer. To overcome the limitations of existing models, we develop human stem cell–based systems that allow us to generate tissue-forming cells and study these processes in a physiologically relevant context.
Selected Publications
- Samajdar A, Amato R, Jo S, Cordes E, Tai A, Raffa GD, Batista LFZ. Exosome-mediated decay of unstable long extendedprecursors of human telomerase RNA is dependent on 5'-cap trimethylation. Genes Dev. 2026 Apr 1;40(7-8):498-516.PubMed Central PMCID: PMC13041540.2.
- Chen L, Batista LFZ. Biogenesis and Regulation of Telomerase during Development and Cancer. Cold Spring Harb PerspectBiol. 2026 Apr 2;18(4) PubMed Central PMCID: PMC12354305.3.
- Jeong HC, Shukla S, Fok WC, Huynh TN, Batista LFZ, Parker R. USB1 is a miRNA deadenylase that regulates hematopoieticdevelopment. Science. 2023 Mar 3;379(6635):901-907. PubMed Central PMCID: PMC10827040.4.
- Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ. Chemical inhibition of PAPD5/7 rescues telomerase function andhematopoiesis in dyskeratosis congenita. Blood Adv. 2020 Jun 23;4(12):2717-2722. PubMed Central PMCID: PMC7322949.5.
- Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM, Batista LFZ. Posttranscriptional modulation of TERCby PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood. 2019 Mar 21;133(12):1308-1312.PubMed Central PMCID: PMC6428664.