Adjunct Associate Professor of Microbiology and Immunology and Associate Professor of Hematology
Fetal Hematopoiesis, Blood Production, Immune Development, Developmental Origin of Disease
Dr. Anna E. Beaudin is an Associate Professor Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah School of Medicine. She holds an adjunct appointment in the Division of Microbiology and Immunology in the Department of Pathology, and holds membership in the Molecular Medicine Program.
The overarching goal of Dr. Beaudin's research is to define the contribution of fetal hematopoiesis, or blood production, to immune development, immune function, and disease susceptibility across the lifespan. Hematopoietic stem cells (HSCs) are responsible for sustaining production of all blood and immune cells across the lifespan. Dr. Beaudin's research focuses on fetal HSCs and the process of fetal hematopoiesis, in which transient HSCs produce a series of distinct blood and immune cells that function to meet the discrete immunological needs of the fetus across development. Fetal-derived immune cells are fundamentally distinct from immune cells produced in adulthood -- they defy conventional phenotypic and functional definitions, and seed developing organs where they persist across the lifespan of the animal to support tissue homeostasis. The Beaudin lab utilizes single-cell analysis, fate-mapping, and in vivo analysis in mouse models to investigate how these specialized cells are made during fetal hematopoiesis, in order to gain insight into the role of these cells in tissue development, regeneration, and disease pathogenesis across the lifespan. We also investigate how perturbation of fetal hematopoiesis by extrinsic stimuli during development (infection, nutrition) shapes susceptibility to immune dysfunction by disrupting immune system establishment and reshaping the trajectory of adult hematopoiesis.
Dr. Beaudin's training is highly interdisciplinary, spanning nutritional sciences, biochemistry, and developmental and stem cell biology, thereby allowing her to make unique contributions to research at the intersection of development, hematopoiesis, and immunology. Originally from Los Angeles, California, Dr. Beaudin completed a B.A. in Psychology and Ph.D. in Nutritional sciences at Cornell University in Ithaca, New York. She continued her postdoctoral work at UC Santa Cruz, where she used a fate-mapping approach to discover a novel, transient hematopoietic progenitor that serves as a cell of origin for fetal-restricted innate-like lymphocytes (Beaudin et al, Cell Stem Cell, 2016; Beaudin & Forsberg, Blood, 2016). Since opening her lab in 2016, Dr. Beaudin's work has been funded by several NIH-funded awards, the Hellman Foundation, and she is a recipient of the Pew Biomedical Scholars Award. Dr. Beaudin is an active member of the International Society of Experimental Hematology, where she serves on the Publications Committee, as well as American Society of Hematology, and the American Association of Immunologists. She was also elected as a council member for the Midwinter Conference of Immunologists. Dr. Beaudin's is an active reviewer for journals including Cell Stem Cell, Stem Cell Reports, Blood, and Nature Communications, and her work has been published in high profile journals such as Cell Stem Cell, Stem Cell Reports, and Development.
References (Selected Publications)
- Lpez DA, Beaudin AE (2021). Layered immunity of the developing thymus. Blood, 137(8), 1003-1004.
- Apostol AC, Lpez DA, Beaudin AE (2020). A "Switch" in Time through Genes Aligned: Unraveling the Genomic Landscape of HSC Development. Cell Stem Cell, 27(5), 695-697.
- Leung GA, Cool T, Valencia CH, Worthington A, Beaudin AE, Forsberg EC (2019). The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. Development, 146(14).
- Boyer SW, Rajendiran S, Beaudin AE, Smith-Berdan S, Muthuswamy PK, Perez-Cunningham J, Martin EW, Cheung C, Tsang H, Landon M, Forsberg EC (2019). Clonal and Quantitative In Vivo Assessment of Hematopoietic Stem Cell Differentiation Reveals Strong Erythroid Potential of Multipotent Cells. Stem Cell Reports, 12(4), 801-815.
- Valentine KM, Davini D, Lawrence TJ, Mullins GN, Manansala M, Al-Kuhlani M, Pinney JM, Davis JK, Beaudin AE, Sindi SS, Gravano DM, Hoyer KK (2018). CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease. J Immunol, 201(1), 31-40.
- Cole C, Byrne A, Beaudin AE, Forsberg EC, Vollmers C (2017). Tn5Prime, a Tn5 based 5' capture method for single cell RNA-seq. Nucleic Acids Res, 46(10), e62.
- Apostol AC, Beaudin AE (2018). Reversing Time: Ezh1 Deficiency Hastens Definitive Hematopoiesis. Cell Stem Cell, 22(3), 285-287.
- Byrne A, Beaudin AE, Olsen HE, Jain M, Cole C, Palmer T, DuBois RM, Forsberg EC, Akeson M, Vollmers C (2017). Nanopore long-read RNAseq reveals widespread transcriptional variation among the surface receptors of individual B cells. Nat Commun, 8, 16027.
- Beaudin AE, Forsberg EC (2016). To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells? Blood, 128(24), 2765-2769.
- Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujjavarapu C, Aaserude E, MacKenzie T, Forsberg EC (2016). A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells. Cell Stem Cell, 19(6), 768-783.
- Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JK, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F (2014). C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity, 42(4), 665-78.
- Beaudin AE, Boyer SW, Forsberg EC (2013). Flk2/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells. Exp Hematol, 42(3), 218-229.e4.
- Abarinov EV, Beaudin AE, Field MS, Perry CA, Allen RH, Stabler SP, Stover PJ (2013). Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. J Nutr, 143(7), 1028-35.
- Boyer SW, Beaudin AE, Forsberg EC (2012). Mapping differentiation pathways from hematopoietic stem cells using Flk2/Flt3 lineage tracing. Cell Cycle, 11(17), 3180-8.
- Beaudin AE, Perry CA, Stabler SP, Allen RH, Stover PJ (2012). Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. Am J Clin Nutr, 95(4), 882-91.
- Beaudin AE, Abarinov EV, Malysheva O, Perry CA, Caudill M, Stover PJ (2011). Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am J Clin Nutr, 95(1), 109-14.
- Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ (2011). Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr, 93(4), 789-98.
- Beaudin AE, Stover PJ (2009). Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol, 85(4), 274-84.
- Beaudin AE, Stover PJ (2007). Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Research. Part C: Embryo Today Reviews, 81(3), 183-203.
- Moon J, Beaudin AE, Verosky S, Driscoll LL, Weiskopf M, Levitsky DA, Crnic LS, Strupp BJ (2007). Attentional dysfunction, impulsivity, and resistance to change in a mouse model of fragile X syndrome. Behav Neurosci, 120(6), 1367-79.
- Lauay C, Komorowski RW, Beaudin AE, Devoogd TJ (2005). Adult female and male zebra finches show distinct patterns of spine deficits in an auditory area and in the song system when reared without exposure to normal adult song. J Comp Neurol, 487(2), 119-26.