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Tamara Bidone

Adjunct Assistant Professor of Biochemistry and Adjunct Assistant Professor of Molecular Pharmaceutics

Biophysics, Molecular Dynamics Simulations, Coarse-graining, Agent-based Modeling, Protein Structure-function Relationship

Tamara Bidone

 

Molecular Biology Program

Biological Chemistry Program

Education

B.S. Polytechnic University of Turin, Italy

M.S. Polytechnic University of Turin, Italy 

PhD Polytechnic University of Turin, Italy 

 

Research

Our research is largely directed towards understanding the structure-function relationship of biological macromolecules and their effects on cellular activity. We study the molecular and macromolecular dynamics of adhesion proteins, and  how their alterations lead to dysfunction and disease. We develop and apply a suite of simulation methods ranging from molecular modeling, bottom-up coarse-graining methods, Brownian dynamics and agent-based mesoscale modeling.

References (Selected Publications)

  1. Lamellipodium is a myosin-independent mechanosensor. Oakes PW, Bidone TC, Beckham Y, Skeeters AV, Ramirez-San Juan GR, Winter SP, Voth GA, Gardel ML. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2646-2651. doi: 10.1073/pnas.1715869115. Epub 2018 Feb 27. PMID: 29487208 Free PMC article.
  2. Integrin-based mechanosensing through conformational deformation. Driscoll TP, Bidone TC, Ahn SJ, Yu A, Groisman A, Voth GA, Schwartz MA. Biophys J. 2021 Oct 19;120(20):4349-4359. doi: 10.1016/j.bpj.2021.09.010. Epub 2021 Sep 10. PMID: 34509509
  3. Computational model demonstrates that Ndc80-associated proteins strengthen kinetochore-microtubule attachments in metaphase. Campbell S, Amin MA, Varma D, Bidone TC. Cytoskeleton (Hoboken). 2019 Nov;76(11-12):549-561. doi: 10.1002/cm.21562. Epub 2019 Oct 11. PMID: 31525284
  4. Computational model of E-cadherin clustering under force. Chen Y, Brasch J, Harrison OJ, Bidone TC. Biophys J. 2021 Nov 16;120(22):4944-4954. doi: 10.1016/j.bpj.2021.10.018. Epub 2021 Oct 21. PMID: 34687721
  5. Formin Cdc12's specific actin assembly properties are tailored for cytokinesis in fission yeast. Homa KE, Zsolnay V, Anderson CA, O'Connell ME, Neidt EM, Voth GA, Bidone TC, Kovar DR. Biophys J. 2021 Aug 3;120(15):2984-2997. doi: 10.1016/j.bpj.2021.06.023. Epub 2021 Jun 30. PMID: 34214524
Last Updated: 9/7/22