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Grzegorz (Greg) Bulaj

Associate Professor of Medicinal Chemistry and Adjunct Assistant Professor of Anesthesiology

Molecular-Behavioral Combination Therapies, Digital Therapeutics, Mobile Medical Apps, Epilepsy, Pain, Depression, Cancer

Greg Bulaj


Biological Chemistry Program


M.Sc. University of Wroclaw, Poland

Ph.D. University of Wroclaw, Poland



The long-term goal of our research is to develop drug-device combination therapies which simultaneously target a disease at molecular and behavioral levels. The molecular-behavioral combination therapies consist of pharmaceutical drugs and disease self-management content which is delivered via digital therapeutics (software as a medical device, or SaMD). This strategy aims to improve both therapy outcomes and medication adherence for chronically-ill patients. Our research includes creating digital content for SaMD to be combined with antiseizure drugs. Examples of our collaborative projects include: (1) an exercise-empowerment mobile game therapy for pediatric oncology patients, and (2) mobile software for people with epilepsy.


  1. Rohaj A and Bulaj G (2023) Digital Therapeutics (DTx) Expand Multimodal Treatment Options for Chronic Low Back Pain: The Nexus of Precision Medicine, Patient Education, and Public Health. Healthcare. 11, 1469.
  2. Giravi HY, Biskupiak Z, Tyler LS, Bulaj G (2022) Adjunct Digital Interventions Improve Opioid-based Pain Management: Impact of Virtual Reality and Mobile Applications on Patient-Centered Pharmacy Care. Front Digital Health 4:884047
  3. Bulaj G, Clark J, Ebrahimi M and Bald E (2021) From Precision Metapharmacology to Patient Empowerment: Delivery of Self-Care Practices for Epilepsy, Pain, Depression and Cancer Using Digital Health Technologies. Front. Pharmacol. 12:612602.
  4. Metcalf CS, Huntsman M, Garcia G, Kochanski AK, Chikinda M, Wanatabe E, Underwood T, Vanegas F, Smith MD, HS White, Bulaj G (2019) Music-enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Towards Preclinical Studies Supporting Development of Digital Therapeutics and their Combinations with Pharmaceutical Drugs. Front Neurol. 10:277.
  5. Afra P, Bruggers CS, Sweney M, Fagatele L, Alavi F, Greenwald M, Huntsman M, Nguyen K, Jones JK, Shantz D and Bulaj G (2018) Mobile Software as a Medical Device (SaMD) for the Treatment of Epilepsy: Development of Digital Therapeutics Comprising Behavioral and Music-Based Interventions for Neurological Disorders. Front. Hum. 
  6. Bruggers CS, Baranowski S, Besaris M, Leonard R, Long D, Schulte E, Shorter A, Stigner R, Mason CC                                                                       Alisa Bedrov A, Ian Pascual I,Bulaj G (2018) A Prototype Exercise-Empowerment Mobile Video Game for Children with Cancer, and its Usability Assessment: Developing Digital Empowerment Interventions for Pediatric Diseases, Front Pediatrics 6:69.
  7. Schriewer K and Bulaj G(2016) Music Streaming Services as Adjunct Therapies for Depression, Anxiety and Bipolar Symptoms: Convergence of Digital Technologies, Mobile Apps, Emotions, and Global Mental Health.Front Publ Health. 4: 217. 
  8. Bulaj G, Ahern MM, Kuhn A, Judkins ZS, Bowen RC, Chen Y. (2016) Incorporating Natural Products, Pharmaceutical Drugs, Self-care and Digital/Mobile Health Technologies into Molecular-Behavioral Combination Therapies for Chronic Diseases. Curr Clin Pharmacol11: 1-18 
  9. Govender M, Bowen RC, German ML, Bulaj G, Bruggers CS (2015) Clinical and Neurobiological Perspectives of Empowering Pediatric Cancer Patients Using Videogames. Games Health J. 4: 1-13
  10. Bulaj G (2014) Combining non-pharmacological treatments with pharmacotherapies for neurological disorders: a unique interface of the brain, drug–device, and intellectual property. Front Neurol. 5:
  11. Bruggers CS, Altizer RA, Kessler RR, Caldwell CB, Coppersmith K, Warner L, Davies B, Paterson W, Wilcken J, D'Ambrosio TA, German ML,Hanson GR, Gershan LA, Korenberg JR, Bulaj G (2012) Patient-empowerment interactive technologies. Sci Transl Med. 4(152): 152ps16
Last Updated: 7/10/23