My lab’s research focus is pathogenic mycobacteria, including the causative agent of tuberculosis, Mycobacterium tuberculosis, and non-tuberculous mycobacteria such as Mycobacterium avium. Our goal is to understand how bacterial strain diversity impacts clinically relevant phenotypes, such as antibiotic resistance, virulence, and vaccine escape. We utilize a combination of high-throughput forward genetic tools, bacterial population genomics, and in vitro and in vivo models to address these questions.