Natalia Harasymowicz
Assistant Professor of Orthopaedic Surgery and Adjunct Assistant Professor of Nutrition & Integrative Physiology
Immune Cells, Arthritis, Obesity
Molecular Biology Program
Education
S.B. Jagiellonian University
M.Sci. Jagiellonian University
Ph.D. University of Edinburgh
Research
Harasymowicz’s lab studies pathogenesis of Osteoarthritis (OA). We utilize novel molecular and cell biology methods to understand the contribution of immune cells in the pathogenesis of osteoarthritis. We aim to define the phenotype of immune cells, mainly macrophages in the synovial joints and their fate during the progression of injury, age, and obesity. By joining our group, students will have the opportunity to learn the basics of immunology, cellular biology, and translational sciences.
References (Selected Publication)
- Harasymowicz NS, Azfer A, Burnett R, Simpson H, Salter DM (2021). Chondrocytes from osteoarthritic cartilage of obese patients show altered adiponectin receptors expression and response to adiponectin. J Orthop Res, 39(11), 2333-2339. (Read full article)
- Harasymowicz NS, Rashidi N, Savadipour A, Wu CL, Tang R, Bramley J, Buchser W, Guilak F (2020). Single-cell RNA sequencing reveals the induction of novel myeloid and myeloid-associated cell populations in visceral fat with long-term obesity. FASEB J, 35(3), e21417. (Read full article)
- Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F (2020). Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity. Sci Adv, 6(19), eaaz7492. (Read full article)
- Harasymowicz NS, Choi YR, Wu CL, Iannucci L, Tang R, Guilak F (2020). Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice. Arthritis Rheumatol, 72(4), 632-644. (Read full article)
- Harasymowicz NS, Clement ND, Azfer A, Burnett R, Salter DM, Simpson AHWR (2017). Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients With Osteoarthritis. Arthritis Rheumatol, 69(7), 1396-1406. (Read full article)