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Xiaoyang Zhang

Assistant Professor of Oncological Sciences

Zhang Photo

B.S. Fudan University

Ph.D. Dartmouth College



Xiaoyang Zhang's Lab Page

Xiaoyang Zhang's PubMed Literature Search


Molecular Biology Program

Biological Chemistry Program

Cancer genomics, Cancer epigenetics, Genome/Epigenome editing, 3D chromatin structure


The Zhang Lab studies how epigenetic and transcriptional dysregulation contributes to cancer development, with a long-term goal of discovering novel therapeutic targets. We apply genome/epigenome analysis and high-throughput screening to generate hypotheses that we test using cutting-edge in vitro and in vivo technologies.

Our research uniquely spans the interface between computational and experimental biology. The research directions include the following:

  *   Study recurrent noncoding genomic/epigenomic alterations in cancer

  *   Identify and characterize novel dependencies in lung cancer by CRISPR screens

  *   Investigate cellular plasticity during cancer development by epigenomic and transcriptomic profiling


Selected Publications:

  1. Zhang X, Choi PS, Francis JM, Gao G, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger A, Giannakis M, Hahn WC, Cherniack AD, Meyerson M. (2018). Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discovery 8, 108-125
  2. Beroukhim R, Zhang X, Meyerson M. (2017). Copy number alterations unmasked as enhancer hijackers. Nature Genetics 49, 5-6
  3. Zhang X*, Choi PS*, Francis JM*, Imielinski M, Watanabe H, Cherniack AD, Meyerson M. (2016). Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nature Genetics 48, 176-182
  4. Bailey SD*, Zhang X*, Desai K, Aid M, Corradin O, Cowper-Sal Lari R, Akhtar-Zaidi B, Scacheri PC, Haibe-Kains B, Lupien M. (2015). ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Nature Communications 2, 6186
  5. Cowper-Sal Lari R*, Zhang X*, Wright JB, Bailey SD, Cole MD, Moore JH, Lupien M. (2012). Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nature Genetics 44, 1191-1198
  6. Zhang X*, Cowper-Sal Lari R*, Bailey SD, Moore JH, and Lupien M. (2012). Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Research 22, 1437-1416

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Last Updated: 5/5/21