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Evolutionary Genetics and Genomics Research Emphasis Area

All biological variation has been shaped by evolutionary forces including mutation, selection, and drift. Their study provides leverage to decipher gene function in health and disease and to predict their future states in evolving populations. The EGG emphasis area focuses on these fundamental forces and the resulting phenotypic variation within a wide range of species. Member labs’ interests range from populations to species and employ genetic models, non-model organisms, genomics, and computation. Specific study areas include population genetics, host-pathogen conflicts, molecular co-evolution, speciation, mutation, trait development and evolution, genomics, genome organization, gene regulation, and directed evolution.

Events

Research in Progress presentations by researchers from any level from participating labs.

Day-long series of talks and posters including an external guest speaker. Initiated pre-pandemic

 

T32 Opportunities

Genetics Training Grant

  • The Training Program in Genetics has been funded by the National Institutes of Health for more than forty years. The program has contributed to landmark discoveries in genetics, including discovery of restriction fragment length polymorphisms, development of a genetic linkage map in humans, and methods for targeted gene disruption in vertebrates.

 

Evolutionary Genetics and Genomics focused Core Facilities

University of Utah researchers have access to numerous state of the art core facilities, resources and support through the Health Sciences Center, Huntsman Cancer Institute, and the University. Cores and resources that are highly utilized by Evolutionary Genetics and Genomics Research Emphasis Area members are:

Core Facilities Website

 

Students

“The evolutionary genetics and genomics community at the U is a fantastic thing to be a part of. There is such a wide range of research being conducted using many different tools. I do solely computational research using mostly publicly available data, but there are also lab members testing evolutionary processes functionally in model systems. I love being able to ask such a wide variety of questions that would be really hard to answer in a traditional genetics experiment set-up.”

Jordan Little, Nathan Clark's Lab

"I think the evolutionary genetics and genomics research area within the human genetics department at the UofU is a supportive and growing community. There is a lot of exciting and interdisciplinary research happening that, as a trainee, is amazing to be a part of because of the educational and experiential opportunities. Although my lab works in evolutionary and population genomics where I have learned several skills in computational research, I have also been able to learn some general principles and approaches of animal models and other wet lab techniques through interest group research presentations and journal clubs. I feel that through my time in the lab and department, I have gained a lot of the skills needed for having a successful career, whatever that may be."

Paige Eberle, Ellen Leffler's Lab

Courses

The University of Utah General Catalog

This course will provide a comprehensive introduction to fundamental concepts and experimental approaches in the analysis and interpretation of experimental genomics data. It will be structured as a series of lectures covering key concepts and analytical strategies. A diverse range of biological question enabled by modern DNA sequencing technologies will be explored including sequence alignment, the identification of genetic variation, structural variation, and ChIP-seq and RNA-seq analysis. Students will learn and apply the fundamental data formats and analysis strategies that underlie computational genomics research. The primary goal of the course is for students to be grounded in theory and have the ability to conduct independent genomic analyses.
This course will explore the molecular, developmental, and genetic mechanisms underlying evolutionary change, with an emphasis on current research in animal biology. Topics include regulatory networks and signaling pathways, modularity, developmental constraints, origin of animals, molecular/developmental origin of diverse body plans and appendages, and genetics of speciation. The class will consist of both lectures and discussions of current literature. Suitable for graduate students at all levels.
This course will cover the fundamentals of population and evolutionary genetics with an emphasis on molecular and sequence-level approaches, including practical exercises in computational analysis aimed at students at all levels of experience. Lectures will cover both theory and experimental studies of the forces that shape genetic variation within and between species.
Theories and methods of molecular population genetics, with emphasis on human examples. How DNA sequence variation is analyzed to infer population history and to identify genes recently subject to selection. Laboratory exercises develop elementary programming skills and show how computation is used to connect models and data.

 

Faculty

Bioscience Faculty

 

Last Updated: 11/12/24